Table 1.
Common microRNA changes identified from the results of next-generation sequencing (NGS).
| microRNA | Expression Level (rpm) | Ratio (AHBE/NHBE) | Expression Level (rpm) | Ratio (CHBE/NHBE) | ||
|---|---|---|---|---|---|---|
| AHBE | NHBE * | CHBE | NHBE * | |||
| hsa-miR-10a-3p | 6.51 | 2.58 | 2.52 | 2.39 | 0.14 | 17.07 |
| hsa-miR-10a-5p | 6937.77 | 2251.48 | 3.08 | 52,697.51 | 24,821.91 | 2.12 |
| hsa-miR-146a-5p | 157.81 | 53.57 | 2.95 | 526.01 | 223.11 | 2.36 |
| hsa-miR-203a | 2852.52 | 1184.56 | 2.41 | 445.33 | 187.00 | 2.38 |
| hsa-miR-3130-5p | 1.92 | 0.65 | 2.95 | 19.10 | 1.67 | 11.44 |
| hsa-miR-365a-5p | 5.18 | 2.58 | 2.01 | 7.50 | 2.79 | 2.69 |
| hsa-miR-548d-5p | 5.47 | 2.42 | 2.26 | 5.12 | 2.37 | 2.16 |
| hsa-miR-487a | 1.04 | 2.74 | 0.38 | 2.39 | 5.86 | 0.41 |
| hsa-miR-873-5p | 1.63 | 9.84 | 0.17 | 1.88 | 8.65 | 0.22 |
* The primary human bronchial epithelial cells (HBEs) used for next-generation sequencing (NGS) included HBE from an asthmatic patient (AHBE), HBE from a patient with chronic obstructive pulmonary disease (CHBE), and HBEs from normal subjects (NHBEs). Because of different timing of the study, different NHBEs were used for the NGS analyses that comparing the expression levels of microRNAs between AHBE and NHBE and between CHBE and NHBE. rpm, read per million.