. 2019 Jan 24;20(3):498. doi: 10.3390/ijms20030498

Table 1.

Inhibitory effects of compounds 3a–3h against AChE and BuChE activity and on d radical scavenging activities.

Comp.	AChE IC₅₀ ± SD (µM) ^a	BuChE IC₅₀ ± SD (µM) ^b	Selectivity for AChE ^c	Selectivity for BuChE ^d	ABTS FRS₅₀ ± SD (mM)	DPPH FRS₅₀ ± SD (mM)
3a	0.453 ± 0.018	0.124 ± 0.037	0.3	3.6	3.1 ± 0.18	14.3 ± 1.46
3b	0.245 ± 0.038	0.618 ± 0.043	2.5	0.4	1.9 ± 0.30	NA
3c	0.589 ± 0.072	0.662 ± 0.053	1.1	0.9	3.6 ± 0.66	NA
3d	0.162 ± 0.018	0.534 ± 0.023	3.3	0.3	4.8 ± 0.66	NA
3e	0.067 ± 0.002	0.153 ± 0.020	2.3	0.4	NA	NA
3f	0.074 ± 0.004	0.062 ± 0.003	0.8	1.2	10.5 ± 1.79	NA
3g	0.073 ± 0.005	0.042 ± 0.006	0.6	1.2	4.8 ± 0.34	NA
3h	0.071 ± 0.005	0.094 ± 0.006	1.3	0.8	NA	NA
THA	0.081 ± 0.009	0.020 ± 0.002	0.24	4.13	NA	NA
Trolox	-	-	-	-	0.040 ± 0.006	0.0049 ± 0.0004

^a IC₅₀: 50% inhibitory concentration (means ± SD of three independent experiments) of AChE. ^b IC₅₀: 50% inhibitory concentration (means ± SD of three independent experiments) of BuChE. ^c Selectivity for AChE: IC₅₀(BuChE)/IC₅₀(AChE). ^d Selectivity for BuChE: IC₅₀(AChE)/IC₅₀(BuChE). * NA = inactive (FRS₅₀ more than 20 mM).