Table 1.
List of differentially expressed genes (DEGs) associated with inflammation/immune response in aged microglia.
| Gene Name | GO Term | Expression Level Old vs. Young | Age/Brain Region | Species | Reference |
|---|---|---|---|---|---|
| Axl | GO:0002376, GO:0045087, GO:0006954 | Up | 24 months/whole brain | Mus musculus | [74] |
| Camp | GO:0045087 | Up | 24 months/whole brain | Mus musculus | [74] |
| Ccl3 | GO:0006954, GO:0050729, GO:0006955 | Up | 24 months/whole brain | Mus musculus | [74] |
| Cd274 | GO:0006955 | Up | 24 months/whole brain | Mus musculus | [74] |
| Cd36 | GO:0006955 | Up | 24 months/whole brain | Mus musculus | [74] |
| Cd74 | GO:0002376, GO:0006955, GO:0019886, GO:0042613 | Up | 24 months/whole brain | Mus musculus | [74] |
| Chst1 | GO:0006954 | Up | 24 months/whole brain | Mus musculus | [74] |
| Clec7a | GO:0045087, GO:0006954 | Up | 24 months/whole brain | Mus musculus | [74] |
| Ctse | GO:0019886 | Up | 24 months/whole brain | Mus musculus | [74] |
| Cxcl13 | GO:0006954, GO:0006955 | Up | 24 months/whole brain | Mus musculus | [74] |
| Cybb | GO:0045087, GO:0006954 | Up | 24 months/whole brain | Mus musculus | [74] |
| H2-aa | GO:0002376, GO:0006955, GO:0019886, GO:0042613 | Up | 24 months/whole brain | Mus musculus | [74] |
| H2-ab1 | GO:0002376, GO:0006955, GO:0019886, GO:0042613 | Up | 24 months/whole brain | Mus musculus | [74] |
| H2-eb1 | GO:0002376, GO:0006955, GO:0019886, GO:0042613 | Up | 24 months/whole brain | Mus musculus | [74] |
| Ifit3 | GO:0002376, GO:0045087 | Up | 24 months/whole brain | Mus musculus | [74] |
| Ifitm2 | GO:0002376 | Up | 24 months/whole brain | Mus musculus | [74] |
| Ifitm3 | GO:0002376, GO:0045087 | Up | 24 months/whole brain | Mus musculus | [74] |
| Lcn2 | GO:0002376, GO:0045087 | Up | 24 months/whole brain | Mus musculus | [74] |
| Lgals3 | GO:0002376, GO:0045087 | Up | 24 months/whole brain | Mus musculus | [74] |
| Ltf | GO:0002376 | Up | 24 months/whole brain | Mus musculus | [74] |
| Ly9 | GO:0002376, GO:0045087 | Up | 24 months/whole brain | Mus musculus | [74] |
| Oasl2 | GO:0002376, GO:0045087, GO:0006955 | Up | 24 months/whole brain | Mus musculus | [74] |
| Rsad2 | GO:0002376, GO:0045087 | Up | 24 months/whole brain | Mus musculus | [74] |
| S100a8 | GO:0002376, GO:0045087, GO:0006954, GO:0050729 | Up | 24 months/whole brain | Mus musculus | [74] |
| S100a9 | GO:0002376, GO:0045087, GO:0006954, GO:0050729 | Up | 24 months/whole brain | Mus musculus | [74] |
| Spp1 | GO:0006954 | Up | 24 months/whole brain | Mus musculus | [74] |
GO:0002376, immune system process; GO:0006954, inflammatory response; GO:0006955, immune response; GO:0019886, antigen processing and presentation of exogenous peptide antigen via MHC class II; GO:0042613, MHC class II protein complex; GO:0045087, innate immune response; GO:0050729, positive regulation of inflammatory response. All gene listed passed the rule that log2 fold change >1 and adjusted p value <0.05.