Table 2.
List of DEGs associated with inflammation/immune response in aged astrocytes.
| Gene Name | GO Term | Expression Level Old vs. Young | Age/Brain Region | Species | Reference |
|---|---|---|---|---|---|
| Akap8 | GO:0002376, GO:0045087 | Up | 24 months/Striatum | Mus musculus | [82] |
| App | GO:0045087 | Up | 24 months/Striatum | Mus musculus | [82] |
| B2m | GO:0006955, GO:0002376, GO:0045087 | Up | 24 months/ Hippocampus, Striatum |
Mus musculus | [82] |
| Bcl6 | GO:0002376, GO:0006954 | Up | 24 months/ Cortex, Striatum |
Mus musculus | [82] |
| Bmp6 | GO:0006954 | Up | 24 months/ Visual cortex, Striatum |
Mus musculus | [82,83] |
| Bst2 | GO:0045087, GO:0002376 | Up | 24 months/Motor cortex | Mus musculus | [83] |
| C3 | GO:0045087, GO:0002376, GO:0006954 | Up | 24 months/Motor cortex, Visual cortex | Mus musculus | [83] |
| C4b | GO:0045087, GO:0006954 | Up | 24 months/Motor cortex, Visual cortex, Striatum | Mus musculus | [82,83] |
| Csf1 | GO:0002376, GO:0045087, GO:0006954 | Up | 24 months/Striatum | Mus musculus | [82] |
| Ctss | GO:0019882, GO:0006955 | Up | 24 months/ Hippocampus, Striatum |
Mus musculus | [82] |
| Cxcl10 | GO:0006955, GO:0006954 | Up | 24 months/ Hippocampus, Striatum |
Mus musculus | [82] |
| Cxcl12 | GO:0006955 | Down | 24 months/Hippocampus | Mus musculus | [82] |
| Cxcl5 | GO:0006954 | Up | 24 months/Visual cortex | Mus musculus | [83] |
| Defb1 | GO:0045087 | Up | 24 months/Motor cortex, Visual cortex | Mus musculus | [83] |
| Enpp2 | GO:0006955 | Down | 24 months/Hippocampus | Mus musculus | [82] |
| Erap1 | GO:0002376 | Up | 24 months/Striatum | Mus musculus | [82] |
| H2-d1 | GO:0019882, GO:0006955, GO:0002376 | Up | 24 months/Cortex, Hippocampus, Striatum | Mus musculus | [82] |
| H2-k1 | GO:0019882, GO:0006955, GO:0002376 | Up | 24 months/ Hippocampus, Striatum |
Mus musculus | [82] |
| Hfe | GO:0019882 | Up | 24 months/Striatum | Mus musculus | [82] |
| Icosl | GO:0002376 | Up | 24 months/Striatum | Mus musculus | [82] |
| Ifit1 | GO:0045087, GO:0002376 | Up | 24 months/Visual cortex, Striatum | Mus musculus | [82,83] |
| Ifit3 | GO:0002376, GO:0045087 | Up | 24 months/Cortex, Striatum | Mus musculus | [82] |
| Ifitm3 | GO:0002376, GO:0045087 | Up | 24 months/Cortex, Striatum | Mus musculus | [82] |
| Ly86 | GO:0002376, GO:0045087, GO:0006954 | Up | 24 months/Striatum | Mus musculus | [82] |
| Nlrp6 | GO:0045087, GO:0002376, GO:0006954 | Up | 24 months/Visual cortex | Mus musculus | [83] |
| Oasl2 | GO:0045087, GO:0002376, GO:0006955 | Up | 24 months/Motor cortex, Visual cortex, Hippocampus, Striatum | Mus musculus | [82,83] |
| Psmb8 | GO:0002376, GO:0019882 | Up | 24 months/Visual cortex, Hippocampus, Striatum | Mus musculus | [82,83] |
| Psmb9 | GO:0002376, GO:0019882 | Up | 24 months/ Hippocampus, Striatum |
Mus musculus | [82] |
| Rsad2 | GO:0045087, GO:0002376 | Up | 24 months/Visual cortex | Mus musculus | [83] |
| Serinc3 | GO:0002376, GO:0045087 | Up | 24 months/Striatum | Mus musculus | [82] |
| Serping1 | GO:0002376, GO:0045087 | Up | 24 months/Striatum | Mus musculus | [82] |
| Tspan2 | GO:0006954 | Up | 24 months/Striatum | Mus musculus | [82] |
| Tyrobp | GO:0045087 | Up | 24 months/Striatum | Mus musculus | [82] |
| Zc3hav1 | GO:0045087, GO:0002376 | Up | 24 months/Visual cortex, Striatum | Mus musculus | [82,83] |
GO:0019882, antigen processing and presentation; GO:0002376, immune system process; GO:0006954, inflammatory response; GO:0006955, immune response; GO:0045087, innate immune response. All gene listed passed the rule that log2 fold change >1 and adjusted p value <0.05.