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. 2019 Jan 24;20(3):506. doi: 10.3390/ijms20030506

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Simvastatin (SVS) increases mRNA expression levels of osteogenic markers in D1 cells. D1 cells (passage 8) were treated with SVS at concentrations of 0 (control: Ctrl), 0.25, and 0.5 µM in basal medium for 3 days. Total RNA was isolated and subjected to real-time PCR analysis. The mRNA expression levels of osteogenic marker genes (bone morphogenetic protein-2 (BMP-2), runt-related transcription factor 2 (Runx2,) alkaline phosphatase (ALP), osteocalcin (OC), and collagen type I) were detected after 3 days of SVS treatment. The gene expression levels are expressed relative to the Ctrl, which is defined as 1. The values presented are the mean ± SD (n = 3). * p < 0.05 and ** p < 0.01 in comparison to the Ctrl.