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. 2019 Jan 29;20(3):573. doi: 10.3390/ijms20030573

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ADAMTS-9 protein and FREEE ¹⁴⁶⁷ neoepitope are present in the 3-week-old mouse joint. M, metaphysis; P, proliferative zone of the growth plate; left-pointing arrow, metaphyseal border; right-pointing arrow, boundary of the secondary centre of ossification; diagonal dotted arrows, columns of calcified cartilage; H, hypertrophic zone of the growth plate. Panels (a,b,e,f) show staining for the FREEE ¹⁴⁶⁷ neoepitope. Panels (c,d,g,h) show staining for ADAMTS-9 protein. Panels (a–d) show cartilage from wildtype mice. Panels (e–h) show cartilage from TS-4/5Δcat mice.