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. 2019 Jan 30;20(3):588. doi: 10.3390/ijms20030588

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Illustrative SMLM next-neighbor density images comparing γH2AX labelling tag numbers and distributions in SkBr3 cells after irradiation (B,D) without particle incubation and after irradiation preceded by uptake of 10 nm Au-NPs into the cytosol (C,E). The intensity of the points represents the number of next neighbors in a 1000 nm radius environment. The control without any treatment (no NP-incubation, and no irradiation) is shown in (A), indicating some repair activity also in untreated cells. Images of irradiated cell were taken at 45 min PI. Scale bar: 1 µm.