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. 2019 Feb 11;20(3):762. doi: 10.3390/ijms20030762

Figure 2.

Figure 2

Metabolic reprogramming of inflammatory macrophages. Ac.CoA: acetyl-coenzyme A ACO2: aconitase mitochondrial, ASL: argininosuccinate lyase, ASS1: argininosuccinate synthase 1, CAD: cis-aconitate decarboxylase, Cis-Aco.: cis-aconitate, Cit.: citrate, Citru.: citrulline, DHAP: dihydroxyacetone phosphate, Fatty A.: fatty acids, FAS; Fatty acid synthase, G3P: Glycerol-3-phsopahe, G3PDH: glycerol-3-phosphate dehydrogenase, G6P: glucose-6-phospate, GLUT1: glucose transporter SLC2A1, HIF1A: hypoxia-inducible factor 1, IDH3: isocitrate dehydrogenase 3, IL1B: interleukine-1β, IRG1: immune-responsive gene 1, LACT: lactate, LDHA: lactate dehydrogenase A, MPC: mitochondrial pyruvate carrier, NADPH: nicotinamide adenine dinucleotide phosphate, NO: nitric oxide, NOS2: inducible nitric oxide synthase, NOX: NADPH oxidase, PFK: phosphofructokinase, PHD: prolyl-hydroxylase, PK: pyruvate kinase PYR: pyruvate, R: arginine, ROS: reactive oxygen species, SDH: succinate dehydrogenase, Suc.: succinate, SLC7A2: arginine transporter, SLC16A3, lactate transporter MCT4, SLC25A10: mitochondrial dicarboxylate carrier, TCA: tricarboxylic acid cycle, TPI: triosephosphate isomerase, VEGF: vascular endothelial growth factor.