Table 1.
Disease Association | SNP Polymorphism | Ref | |||||
---|---|---|---|---|---|---|---|
Promoters | 5’-UTR | ||||||
−1297 C/T | −656 G/T | −607 C/A | −137 G/C | +113 T/T | |||
rs360719 | rs1946519 | rs1946518 | rs187238 | rs360718 | |||
Chronic viral infection | HBV | ND | ND | + | + | ND | [373] |
HCV | ND | ND | − | + | ND | [374] | |
Periodontitis | ND | ND | + | + | ND | [375] | |
ND | ND | − | − | ND | [376] | ||
Autoimmune diseases | SLE | ND | ND | − | ND | ND | [377] |
+a | ND | +a | +b | ND | [378] | ||
ND | ND | +c | − | ND | [379] | ||
+ | ND | +a | − | ND | [380] | ||
Behcet’s disease | ND | ND | + | ND | ND | [381] | |
RA | ND | ND | − | ND | ND | [377] | |
ND | ND | +c | − | ND | [379] | ||
ND | ND | +b | − | ND | [382] | ||
T1D | ND | ND | − | ND | ND | [377] | |
ND | ND | + | − | ND | [383] | ||
ND | ND | +b | − | ND | [384] | ||
CD | ND | − | + | + | + | [385] | |
ND | ND | − | ND | ND | [377] | ||
UC | ND | ND | − | ND | ND | [377] | |
Ischemic stroke | ND | ND | + | − | ND | [386] | |
Cancer | Total cancer | ND | ND | + | − | ND | [387] |
ND | ND | − | +b | ND | [388] | ||
ND | ND | +b | ND | ND | [389] | ||
ND | ND | ND | +b | ND | [390] | ||
Nasopharyngeal cancer | ND | ND | + | + | ND | [388] | |
ND | ND | ND | + | ND | [387] | ||
ND | ND | ND | + | ND | [390] | ||
ND | ND | + | ND | ND | [389] | ||
ND | ND | + | ND | ND | [391] | ||
Esophageal cancer | ND | ND | + | ND | ND | [389] | |
Gastric cancer | ND | ND | + | ND | ND | [388] | |
Head and neck cancer | ND | ND | ND | + | ND | [392] | |
Hepatocellular carcinoma | ND | ND | − | − | ND | [393] | |
Recurrent pregnancy loss | ND | ND | + | + | ND | [394] | |
ND | ND | − | + | ND | [395] | ||
Polycystic ovary syndrome | ND | ND | − | − | ND | [396] |
+; significant association between the variant and disease. −; no significant association between the variant and disease. +a; association in European/Caucasian populations, but not in Asian populations. +b; association in Asian populations, but not in European/Caucasian populations. +c; association in Chinese populations, but not in Asian populations. ND; not determined. Abbreviations: HBV, hepatitis B virus; HCV, hepatitis C virus; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; T1D, type 1 diabetes mellitus; CD, Crohn’s disease; UC, ulcerative colitis.