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. 2019 Jan 25;20(3):508. doi: 10.3390/ijms20030508

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CG2007745 treatment suppresses the increase in myofibroblast markers observed in the kidneys of deoxycorticosterone acetate (DOCA)-salt hypertensive (DSH) rats. (a) Semiquantitative immunoblotting analysis of αSMA and fibronectin in the kidney. Densitometric analysis revealed that the protein expression of αSMA and fibronectin was increased in DSH rats compared to that in controls, which was counteracted by CG200745 treatment (DSH + CG); * p < 0.05 compared to controls, ^# p < 0.05 compared to DSH group. (b) Immunoperoxidase microscopy of αSMA in the cortex. Increased immunolabeling was observed in DSH rats, which was reversed by CG200745 treatment. Magnification: 100×.