Table 2.
Changes in renal function among experimental groups of rats.
| Parameter | Control | DSH | DSH + CG200745 |
|---|---|---|---|
| BUN | 14.8 ± 0.4 | 21.2 ± 5.36 | 19.7 ± 3.41 |
| Creatinine | 0.24 ± 0.05 | 0.31 ± 0.08 | 0.25 ± 0.03 |
| Serum Na | 120.0 ± 4.5 | 118.3 ± 5.5 | 125.5 ± 3.4 |
| Urine Na | 303.0 ± 11.5 | 159.3 ± 10.64 * | 169.5 ± 9.70 * |
| FENa | 2.4 ± 0.67 | 12.3 ± 3.07 * | 9.9 ± 2.68 |
| ACR (mg/gCr) | 297.1 ± 197.3 | 5864.0 ± 662.2 * | 3681.1 ± 267.3 *,# |
Values are expressed as the mean ± SE. These values were measured on the last day of experiments. BUN, blood urea nitrogen, P-Na, plasma sodium; FENa, fractional excretion of sodium into urine; ACR, albumin-to-creatinine ratio; Cr, Creatinine; DSH, deoxycorticosterone acetate salt hypertensive rats. * p < 0.05, when DHS or DSH + CG200745 groups were compared to control group. # p < 0.05, when DSH + CG200745 group was compared to DSH group.