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. 2019 Jan 24;20(3):494. doi: 10.3390/ijms20030494

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proposed hydrolysis metabolites of acylglycosides flavones and docking score analysis of their inhibitory abilities on α-glucosidase (a) and HMG-CoA reductase (b). Among camelliquercetisides, metabolites Mq.3 and prototype Cp.2 (camelliquercetiside F) exhibited excellent inhibitory activities on α-glucosidase and HMG-CoA reductase at −8.8 kcal/mol and −9.0 kcal/mol, respectively. For camellikaempferosides, metabolites Mk.3 exhibited good inhibitory activities on α-glucosidase at −8.7 kcal/mol, Cp.4, Mk.3 and Mk.4 were calculated as the good inhibitors on HMG-CoA reductase.