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. 2019 Feb 2;20(3):653. doi: 10.3390/ijms20030653

Figure 2.

Figure 2

Macroscopy and X-ray microtomography (µCT) of treated defects after 6 months in vivo. (a) Shown are the best and worst µCT images and the corresponding macroscopic appearance per group. (b) International Cartilage Repair Society (ICRS) score determined by three blinded observers resulted in a significantly better score of empty defects compared to both treatment groups. Boxes represent first and third quartiles, medians are given as horizontal lines, whiskers are maximal and minimal values, individual values (mean of all three observers) are depicted as circles. *: p ≤ 0.05 vs. other groups (Mann–Whitney-U test (MWU), Bonferroni correction). Zonal n = 9, non-zonal n = 9, control n = 6. (c) Quantification of bone volume/total volume 6 months after treatment. Mean ± SD. *: p ≤ 0.05 vs. other groups (ANOVA, Bonferroni correction). Zonal n = 9, non-zonal n = 9, control n = 6. (d) Bone loss after treatment with zonal and non-zonal PCL-enforced starPEG constructs and in empty control defects over 6 months. Mean percentage of bone loss ± SD per group compared to day 0 defects (n = 4). *: p ≤ 0.05 vs. control (ANOVA, Bonferroni correction). Zonal n = 9, non-zonal n = 9, control n = 6.