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Hydrogel persistence in the zonal and non-zonal groups after 6 months in vivo. Overview of representative defects after treatment with zonal (a,c) and non-zonal (b,d) constructs. Black arrows: hydrogel fragments. Rectangles: area of higher magnification shown in (c) and (d). Hydrogel fragments outside of the PCL enforcement pressed into the subchondral bone indicated by dotted lines. Scale bar: 500 µm (a,b), 50 µm (c,d).
