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. 2019 Feb 2;20(3):653. doi: 10.3390/ijms20030653

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Evaluation by modified O’Driscoll score. (a) Best and worst results per group according to histological scoring. Safranin O/Fast Green staining. Scale bar: 500 µm. (b) Best cell morphology and collagen type II deposition of regeneration tissue in each group after 6 months in vivo. Top: overview. Scale bar: 500 µm. Bottom: area of magnification. Scale bar: 100 µm. (c) Histological evaluation of defect repair after 6 months in vivo rated by three blinded observers using a modified O’Driscoll score. Boxes represent first and third quartiles, medians are given as horizontal lines, whiskers are maximal and minimal values, individual values (mean of all three observers) are depicted as circles. *: p ≤ 0.05 vs. control (MWU, Bonferroni correction). Zonal n = 9, non-zonal n = 9, control n = 6.