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. 2019 Feb 7;20(3):716. doi: 10.3390/ijms20030716

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Time-kill curves of oxacillin shown by plots of mean values for the log₁₀ of the numbers of CFU/mL versus time for two representative clinical S. aureus WTs (a,c) and corresponding SCVs (b,d) tested against oxacillin. The threshold implicates a ≥3 − log₁₀ decrease in CFU/mL. Time-kill curves for each strain were performed in triplicate (mean ± standard deviation). Asterisks denote statistical difference of the respective concentration of oxacillin used (defined by matching colors) with respect to the untreated growth control at 1 h; p ≤ 0.001 by one-way ANOVA.