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. 2019 Jan 22;20(3):476. doi: 10.3390/ijms20030476

Figure 1.

Figure 1

Changes in particle size frequencies and solubility of indomethacin in indomethacin nanoparticles (IND-NPs). (A) Particle size frequencies of indomethacin in IND-MPs; (B–E) Particle size frequencies (B,C), atomic force microscope (AFM) image (D), and solubility (E) of indomethacin in IND-NPs. Data of Figure 1A,B were obtained by a laser diffraction particle size analyzer, and Figure 1C was measured using the dynamic light-scattering method. Figure 1D was observed by SPM-9700. n = 5. *P < 0.05 vs. IND-MPs. The particle size of indomethacin in IND-NPs was 50–200 nm, and 90.6% of indomethacin in the IND-NPs was of solid type (not dissolved type).