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. 2019 Jan 22;20(3):476. doi: 10.3390/ijms20030476

Figure 4.

Figure 4

Penetration of IND-NPs through Caco-2 cell monolayers treated with endocytosis inhibitors. (A,B) Accumulation of indomethacin in the Caco-2 cell monolayers. (C,D) Penetration of indomethacin through Caco-2 cell monolayers. (E,F) Number of indomethacin nanoparticles in the basolateral side of Caco-2 cell monolayers. Nys-Dyn indicates co-treatment with nystatin and dynasore. n = 5–9. *P < 0.05 vs. vehicle for each category. Dynasore significantly attenuated the accumulation and penetration of indomethacin nanoparticles in Caco-2 cell monolayers.