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. 2019 Jan 22;20(3):476. doi: 10.3390/ijms20030476

Figure 5.

Figure 5

Endocytosis enhances the penetration of indomethacin nanoparticles in the jejunum. (A,B) Changes in the penetration profile (A) and area under the drug concentration-time curve in the reservoir chamber (AUC) (B) of indomethacin nanoparticles in the jejunum under 4 °C or 37 °C conditions. (C–F) Changes in the penetration profile (C,E) and AUC (D,F) of indomethacin nanoparticles in jejunum treated with endocytosis inhibitors. Nys-Dyn indicates co-treatment with nystatin and dynasore. n = 5–8. *P < 0.05 vs. 37 °C conditions. #P < 0.05 vs. vehicle for each category. Dynasore significantly attenuated the penetration of indomethacin nanoparticles in the jejunum.