Table 1.
Pharmacokinetic parameters for IND-NPs penetration in jejunum treated under cold (4 °C) temperature conditions or with endocytosis inhibitors.
| Treatment | Jc (pmol/cm2/h) | Kp (×10−5/h) | Km (×10−3) | τ (h) | D (×10−3 cm2/h) |
|---|---|---|---|---|---|
| Normal (37 °C treatment) | 2.6 ± 0.6 | 5.0 ± 1.1 | 1.6 ± 0.4 | 0.69 ± 0.12 | 2.7 ± 0.6 |
| 4 °C treatment | 0.2 ± 0.1*,# | 0.3 ± 0.1*,# | 0.2 ± 0.1*,# | 1.16 ± 0.18*,# | 1.4 ± 0.3*,# |
| Vehicle | 3.9 ± 1.0 | 7.5 ± 1.5 | 2.6 ± 0.3 | 0.72 ± 0.11 | 2.5 ± 0.4 |
| Nystatin | 3.6 ± 0.9 | 6.9 ± 1.3 | 2.4 ± 0.3 | 0.72 ± 0.10 | 2.6 ± 0.4 |
| Dynasore | 1.9 ± 0.1*,# | 3.9 ± 0.4*,# | 1.9 ± 0.6*,# | 0.85 ± 0.15 | 2.0 ± 0.7 |
| Rottlerin | 3.8 ± 1.0 | 7.1 ± 1.1 | 2.5 ± 0.4 | 0.70 ± 0.13 | 2.3 ± 0.4 |
| Cytochalasin D | 3.9 ± 1.2 | 7.3 ± 1.3 | 2.6 ± 0.5 | 0.71 ± 0.11 | 2.3 ± 0.4 |
| Nys-Dyn | 0.7 ± 0.2*,# | 1.2 ± 0.4*,# | 0.5 ± 0.1*,# | 0.71 ± 0.27 | 2.3 ± 0.7 |
The data in Figure 5A,C,E were calculated according to Equations (1)–(3). n = 5–8. *P < 0.05, vs. Normal for each category. #P < 0.05, vs. Vehicle for each category.