Table 2.
Pharmacokinetic parameters for IND-NPs penetration in the ileum treated under cold (4 °C) temperature conditions or with endocytosis inhibitors.
| Treatment | Jc (pmol/cm2/h) | Kp (×10−4/h) | Km (×10−3) | τ (h) | D (×10−3 cm2/h) |
|---|---|---|---|---|---|
| Normal (37 °C treatment) | 7.4 ± 1.1 | 1.3 ± 0.2 | 8.9 ± 1.3 | 1.21 ± 0.14 | 1.4 ± 0.1 |
| 4 °C treatment | – | – | – | – | – |
| Vehicle | 7.5 ± 1.0 | 1.4 ± 0.3 | 9.0 ± 0.9 | 1.18 ± 0.11 | 1.5 ± 0.2 |
| Nystatin | 5.0 ± 1.4*,# | 0.9 ± 0.2*,# | 8.1 ± 1.8 | 1.65 ± 0.37 | 1.3 ± 0.4 |
| Dynasore | 2.4 ± 0.1*,# | 0.5 ± 0.1*,# | 2.6 ± 0.7*,# | 0.95 ± 0.21 | 1.9 ± 0.4 |
| Rottlerin | 6.8 ± 0.7 | 1.0 ± 0.2 | 8.7 ± 1.0 | 1.09 ± 0.11 | 1.5 ± 0.4 |
| Cytochalasin D | 7.7 ± 1.4 | 1.4 ± 0.3 | 9.1 ± 0.9 | 1.14 ± 0.13 | 1.5 ± 0.3 |
| Nys-Dyn | 1.4 ± 0.4*,# | 0.3 ± 0.1*,# | 1.9 ± 0.4*,# | 0.92 ± 0.20 | 1.8 ± 0.3 |
The data in Figure 6A,C,E were calculated according to Equations (1)–(3). n = 5–8. *P < 0.05, vs. Normal for each category. #P < 0.05, vs. Vehicle for each category.