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. 2019 Jan 23;20(3):487. doi: 10.3390/ijms20030487

Figure 2.

Figure 2

Properties of Zn2+ binding to the third repeat unit of the microtubule-binding domain of tau (tau-R3). (A) Calorimetric titration of Zn2+ to tau-R3. The top panel represents the raw data for sequential two-μL injections of Zn2+ into tau-R3. The bottom panel shows the plot of the heat evolved (kilocalories) per mole of Zn2+ added against the molar ratio of Zn2+ to tau-R3. The data (solid square) was best fitted to a model with a single set of identical sites, and the solid line represents the best fit. (B) Spectrophotometric titration of Zn2+ to tau-R3, Zn2+/tau-R3 ratio ranges from 0–0.5.