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. 2019 Feb 4;20(3):668. doi: 10.3390/ijms20030668

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cannabis/Cannabinoids administration for GVHD prophylaxis. (A) Recipient BALB/c mice received lethal whole-body irradiation and were reconstituted with 8 × 10⁶ donor C57BL/6 bone marrow cells and 2 × 10⁶ spleen cells. Cannabis/cannabinoids were administered IP every other day, for 2 weeks from the day of transplantation. The clinical condition of the mice was evaluated for up to 67 days after transplantation. (B) Survival curve. Differences between control and THC BDS as well as CBD BDS is significant. The difference between THC and THC BDS is also significant. Data are summarized from two independent experiments, six mice/group in each experiment. (C) Average GVHD score (Days 15–26). Differences between THC BDS/CBD BDS to the control group are significant. The same control group is shown in the left and right graph.