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. 2019 Feb 7;20(3):714. doi: 10.3390/ijms20030714

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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AN7 treatment reduces CD31, vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2). Representative images of laser lesion sites from mice treated with IP 20 mg/kg AN7 or saline (control), from day 3 post laser photocoagulation. Sequential cryosections are stained for endothelial cells marker CD31 (green; A,D), VEGF (red; B,E), and FGF-2 (purple; C,F). Cells nuclei are stained with DAPI (blue). GCL, Ganglion Cells Layer; INL, Inner Nuclear Layer; ONL, Outer Nuclear Layer; RPE, Retinal Pigmented Epithelium; C, Choroid. Scale bar, 50 µm. (G) Quantification of CD31 staining in laser applied eyes. (H) Quantification of VEGF staining in laser applied eyes. (I) Quantification of FGF-2 staining in laser applied eyes.