Table 4.
Summary of significant up-regulated stress-related proteins identified in iTRAQ of hADSCs treated with AECK.
| AECK Stress | Accession | Name | GO | Biological Process | Peptides (95%) | Fold Change | p-Value |
|---|---|---|---|---|---|---|---|
| P01892 | HLA class I histocompatibility antigen, A-2 alpha chain | GO:0060333 | interferon-gamma-mediated signaling pathway | 4 | 1.4692 | 0.01600371 | |
| P04083 | Annexin A1 | GO:0006954 | inflammatory response | 45 | 1.3066 | 0.00108737 | |
| P04264 | Keratin, type II cytoskeletal 1 | GO:0006979 | response to oxidative stress | 13 | 2.0287 | 0.00100892 | |
| P06396 | Gelsolin | GO:0006921 | cellular component disassembly involved in apoptosis | 25 | 1.3732 | 2.05 × 10−13 | |
| P09429 | High mobility group protein B1 | GO:0002437 | inflammatory response to antigenic stimulus positive regulation of apoptosis | 16 | 1.1563 | 0.00754318 | |
| P11413 | Glucose-6-phosphate 1-dehydrogenase | GO:0034599 | cellular response to oxidative stress | 23 | 1.2994 | 0.00129321 | |
| P15121 | Aldose reductase | GO:0006950 | response to stress | 9 | 1.3973 | 0.00414161 | |
| P16070 | CD44 antigen | GO:0060333 | interferon-gamma-mediated signaling pathway | 15 | 1.3484 | 8.89 × 10−5 | |
| P30044 | Peroxiredoxin-5, mitochondrial | GO:0034614 | cellular response to reactive oxygen species inflammatory response | 9 | 1.3299 | 0.00063648 | |
| P35611 | Alpha-adducin | GO:0006921 | cellular component disassembly involved in apoptosis | 12 | 1.5308 | 4.06 × 10−12 | |
| P51572 | B-cell receptor-associated protein 31 | GO:0006921 | cellular component disassembly involved in apoptosis | 7 | 1.4834 | 0.00252419 | |
| P61586 | Transforming protein RhoA | GO:0050772 | positive regulation of axonogenesis | 16 | 1.1675 | 0.00013793 | |
| P63000 | Ras-related C3 botulinum toxin substrate 1 | GO:0008624 | induction of apoptosis by extracellular signals | 7 | 1.6642 | 3.48 × 10−6 | |
| P63000 | Ras-related C3 botulinum toxin substrate 1 | GO:0006954 | inflammatory response | 7 | 1.6642 | 0.00016355 | |
| P63241 | Eukaryotic translation initiation factor 5A-1 | GO:0006917 | induction of apoptosis | 20 | 1.4873 | 6.36 × 10−12 | |
| Q02952 | A-kinase anchor protein 12 | GO:0030819 | positive regulation of cAMP biosynthetic process | 17 | 1.3261 | 0.0067851 | |
| Q03135 | Caveolin-1 | GO:0009267 | cellular response to starvation; inactivation of MAPK activity; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt receptor signaling pathway; response to hypoxia | 7 | 3.1097 | 0.02121297 | |
| Q13813 | Spectrin alpha chain | GO:0006921 | cellular component disassembly involved in apoptosis | 71 | 1.2908 | 0.00131438 | |
| Q15149 | Plectin | GO:0006921 | cellular component disassembly involved in apoptosis | 174 | 1.3019 | 2.20 × 10−9 | |
| Q9NR28 | Diablo homolog, mitochondrial | GO:0008625 | induction of apoptosis via death domain receptors | 6 | 1.2655 | 2.20 × 10−9 |