Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pathways that lead to an accumulation of cholesterol: Activation of SREBP transcription factor induces cholesterol. This is induced by activation of PI3K/Akt/mTOR signaling, cancer gene RAS, and dysregulation by TP53. The accumulation of cholesterol in the cell promotes survival and inhibits apoptosis. T-bar in red denotes inhibition.
