Figure 3.

Mevalonate pathway as an important metabolic pathway: The mevalonate pathway is regulated by HMG CoA reductase (HMGCR), and this enzyme is targeted by statins to decrease plasma cholesterol. Fibrates target the mevalonate pathway by inhibiting acetoacetyl coenzyme A. This reverses the effects of cholesterol to inhibit cell proliferation and trigger apoptotic parameters. Downregulating the pathway also suppresses production of farnesyl pyrophosphate and geranylgeranyl phosphate to inhibit the invasive properties of cancer cells. T-bars in red denote inhibition.