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Statin therapy and downstream consequences: Statins block transcription of NFkB. This decreases expression of anti-apoptotic BclXL and inhibits cancer cell proliferation. Inhibition of NFkB also increases expression of pro-apoptotic phosphatase and tensin homolog (PTEN). PTEN inhibits PI3 kinase, and therefore also inhibits the target of PI3 kinase, Akt kinase, which are both associated with the anti-apoptotic properties of cancer cells. T-bars in red denote inhibition.
