Table 2.

Baseline CSF Immune Profiles by CD4 Groups

Baseline CSF Biomarker	Baseline CD4 < 50 cells/μL		Baseline CD4 50–99 cells/μL		Baseline CD4 ≥ 100 cells/μL		P valuea
	N	Median (IQR)	N	Median (IQR)	N	Median (IQR)
IL-1β	249	0.5 (≤0.4–1.7)	67	0.7 (≤0.4–1.6)	29	1.1 (≤0.4–2.7)	.12
IL-2	249	2.1 (≤0.6–8.0)	67	2.3 (≤0.6–8.2)	29	2.2 (≤0.6–6.3)	.91
IL-4	249	1.1 (≤0.4–2.5)	67	0.8 (≤0.3–1.7)	29	1.1 (≤0.5–2.4)	.12
IL-5	249	0.5 (≤0.4–1.8)	67	1.4 (≤0.4–3.4)	29	1.1 (≤0.4–3.7)	.002
IL-6	249	168 (46.7–622)	67	270 (75.1–1543)	29	519 (303–4062)	.004
IL-7	249	4.1 (1.9–10.7)	67	4.6 (2.3–10.8)	29	6.2 (2.7–17.6)	.42
IL-8	249	430 (211–1051)	67	768 (272–1292)	29	1069 (402–1717)	.006
IL-10	249	12.5 (6.6–23.3)	67	13.3 (5.2–25.2)	29	19.6 (5.8–51.8)	.10
IL-13	249	7.3 (2.0–39.9)	67	22.8 (9.6–95.6)	29	65.6 (10.7–130)	<.001
IL-17	249	16.3 (5.5–37.5)	67	15.9 (1.3–37.8)	29	14.5 (8.2–29.6)	.91
G-CSF	249	51.8 (26.1–127)	67	70.1 (32.7–153)	29	87.8 (39.5–209)	.06
GM-CSF	249	283 (228–435)	67	242 (197–363)	29	340 (267–424)	.02
IFN-γ	249	38.3 (16.2–87.6)	67	45.9 (14.6–118.0)	29	89.0 (31.7–218)	.008
IFN-γ/IL-13 ratio	249	5.1 (1.0–15.1)	67	1.4 (0.3–10.3)	29	2.7 (0.6–8.7)	.008
MCP1 (CCL2)	249	680 (261–1854)	67	495 (210–1027)	29	213 (132–598)	.002
TNF-α	249	9.5 (3.9–21.5)	67	13.1 (6.8–40.5)	29	10.2 (4.8–44.8)	.06

Abbreviations: CSF, cerebrospinal fluid; G-CSF, granulocyte colony stimulating factor; GM-CSF, granulocyte-macrophage colony stimulating factor; IFN-γ, interferon-gamma; IL, interleukin; MCP1, monocyte chemotaxis protein-1 (CCL2 chemokine); TNF-α, tumor necrosis factor-alpha.

^aWilcoxon Test. Values in pg/mL. Supplemental Table 1 provides distribution by 18-week survival or mortality outcomes.