Table 1.
General characteristics of the study participants1
| Placebo group (n = 25) |
Crocin group (n = 25) |
P 2 | |
|---|---|---|---|
| Age (y) | 41.4 ± 8.8 | 40.1 ± 9.3 | 0.63 |
| Height (cm) | 171.2 ± 7.5 | 171.6 ± 8.4 | 0.84 |
| Weight at study baseline (kg) | 70.1 ± 8.5 | 68.9 ± 12.1 | 0.68 |
| Weight at the end-of-trial (kg) | 69.7 ± 8.6 | 69.0 ± 11.7 | 0.81 |
| Weight change (kg) | −0.4 ± 1.6 | 0.08 ± 1.4 | 0.23 |
| BMI at study baseline (kg/m2) | 23.9 ± 2.9 | 23.3 ± 3.6 | 0.51 |
| BMI at the end-of-trial (kg/m2) | 23.8 ± 3.0 | 23.4 ± 3.6 | 0.66 |
| BMI change (kg/m2) | −0.1 ± 0.5 | 0.05 ± 0.5 | 0.19 |
| Education (%) | |||
| Illiterate | 5 (20) | 7 (28) | |
| Elementary | 5 (20) | 7 (28) | |
| Intermediate | 12 (48) | 10 (40) | 0.58† |
| Diploma | 2 (8) | 0 (0) | |
| High educated | 1 (4) | 1 (4) | |
| Marital status (%) | |||
| Single | 8 (32) | 5 (20) | |
| Married | 5 (20) | 8 (32) | 0.50† |
| Widow/Divorced | 12 (48) | 12 (48) | |
| Job (%) | |||
| Unemployed | 16 (64) | 18 (72) | |
| Employed | 2 (8) | 1 (4) | 0.76† |
| Others | 7 (28) | 6 (24) | |
| Use of other drugs (%) | |||
| None | 20 (80) | 19 (76) | |
| Benzodiazepine | 2 (8) | 3 (12) | 0.89† |
| Antidepressants (SSRIs) | 3 (12) | 3 (12) | |
| Methadone dose (mL/d) | 19.2 ± 6.2 | 17.2 ± 5.9 | 0.25 |
| Duration of MMT (y) | 6.2 ± 2.6 | 5.5 ± 1.9 | 0.33 |
aData are mean ± SDs
bObtained from independent t-test
cObtained from Pearson Chi-square test
SSRIs selective serotonin reuptake inhibitors