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. 2019 Feb 22;24:15. doi: 10.1186/s11658-019-0142-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — MiRNA expression in the kidney from septic mice. HO-1-related miRNAs were predicted using online software TargetScan (www.targetscan.org) and miRDB (http://www.mirdb.org/miRDB/), and the expression levels of 17 miRNAs were measured by RT-qPCR assays (a). After treatment with honokiol, the expression of miR-218-5p was measured using RT-qPCR in the kidney (b). Spearman’s rank analysis was used to identify the correlation between HO-1 and miR-218-5p expression levels in the kidney of septic mice with CLP or CLP combined with honokiol treatment (c). Values are expressed as mean ± SEM, n = 10 in Con or H + CLP group and n = 8 in CLP or L + CLP group. ^* P < 0.05, ^** P < 0.01, ^*** P < 0.001, versus control group; ^## P < 0.01 versus CLP group