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. 2019 Feb 22;24:15. doi: 10.1186/s11658-019-0142-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Honokiol blocks LPS-induced cell growth inhibition and apoptosis by targeting miR-218-5p/HO-1. The expression levels of miR-218-5p were measured using RT-qPCR assays in the kidney from septic mice with or without honokiol treatment (a) and in LPS-stimulated GMCs with or without honokiol treatment (b). GMCs were exposed to different conditions, cell viability was measured by CCK-8 assay (c); cell apoptosis was performed by flow cytometry (d and e); the mRNA (f) and protein (g) expression levels of HO-1 were measured by RT-qPCR and western blotting, respectively. Values are expressed as mean ± SEM, n = 3 in each group. ^* P < 0.05 versus control group; ^# P < 0.05 versus LPS treated group; ^& P < 0.05 versus honokiol+ LPS treated group