FIG. 4.

Patterns of brain pathology from Experimental Phase 3. (A, D, E) H&E-stained sections showing acute hypoxic-ischemic type injury of cortex with red neurons. (A) Stitch of H&E stained showing damaged gray matter (GM) adjacent to normal appearing white matter (WM). (D, E) Photomicrographs at higher magnification demonstrating red neurons and vacuolization of neurons and neuropil. (D) Representative sections of each injured piglet depicting the area of microscopic tissue damage ipsilateral or contralateral to the focal impact (SDH, cortical impact, mass effect; yellow: damaged tissue, gray: normal tissue). (B, C) Maps demonstrating the hemispheric microscopic tissue damage of one piglet (365) rostral to caudal (section number corresponds to Fig. 3F). H&E, hematoxylin and eosin.