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. 2019 Feb 9;36(5):815–833. doi: 10.1089/neu.2018.5736

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© Beth A. Costine-Bartell et al., 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 5. — Brain pathology from Experimental Phase 3. (A,B) APP in the white matter (WM). (A) Axonal spheroids positive for APP (brown) in the WM of the cortex adjacent to the gyri that underwent cortical impact. (B) APP-positive neurites revealing additional WM injury that appeared normal via H&E. (C) APP-positive neurons in the gray matter (GM). (D) A low power stitch of photomicrographs demonstrating a geographic pattern of APP in the internal capsule (WM) and adjacent GM observed in one piglet (359). (E) Albumin (brown) in sham piglets was restricted to blood vessels. (F) In injured cortex, albumin was extravasated from blood vessels. (G) Active caspase-3 (brown) was widespread in sham piglets, and was not specific to damage in this age of piglet. H&E, hematoxylin and eosin.