Table 3.
Pre-injury | Post-injury | Sacrifice | |
---|---|---|---|
Base excess (BEEcf) (mmol/L) | |||
Group 1 | 5.25 ± 0.63a | -2.75 ± 2.84b | 0.00 ± 2.00a,b |
Group 2 | 4.50 ± 1.32a | 2.25 ± 1.31b | 1.67 ± 0.67a,b |
Group 3 | 4.00 ± 0.84a | -5.80 ± 4.33b | -3.75 ± 6.55a,b |
Sham | 7.00 ± 1.00a | 3.00 ± 2.52b | 6.00 ± 0.00a,b |
Total CO2 (mmol/L) | |||
Group 1 | 29.5 ± 0.65a | 23.7 ± 2.59b | 27.0 ± 2.00a,b |
Group 2 | 27.7 ± 1.70a | 25.5 ± 1.26b | 28.0 ± 1.53a,b |
Group 3 | 28.8 ± 1.07a | 22.0 ± 2.86b | 28.0 ± 1.53a,b |
Sham | 32.5 ± 1.50a | 28.7 ± 1.45b | 31.0 ± 0.00a,b |
Oxygen saturation (%) | |||
Group 1 | 99.0 ± 0.58a | 93.2 ± 2.81a | 94.5 ± 2.50a,b |
Group 2 | 98.0 ± 0.9a | 96.7 ± 1.11a | 98.5 ± 1.50a |
Group 3 | 63.0 ± 19.4b* | 70.2 ± 19.6b* | 68.8 ± 16.1b* |
Sham | 81.5 ± 4.50a,b | 75.7 ± 6.84a,b | 95.0 ± 0.00a,b |
Sodium (mmol/L) | |||
Group 1 | 137 ± 0.75a | 139 ± 0.50b,c | 141 ± 0.88b,c |
Group 2 | 137 ± 2.33a | 141 ± 0.63b,c | 141 ± 0.58b,c |
Group 3 | 137 ± 0.75a | 141 ± 0.89b,c | 143 ± 1.80b,c |
Sham | 138 ± 1.00a | 142 ± 2.96b,c | 139 ± 0.00b,c |
Glucose (mg/dL) | |||
Group 1 | 109 ± 14.2a | 162 ± 3.90b | 136 ± 17.5a,b |
Group 2 | 126 ± 24.8a | 149 ± 11.4b | 118 ± 3.00a,b |
Group 3 | 121 ± 5.79a | 160 ± 20.4b | 114 ± 17.1a,b |
Sham | 74.5 ± 9.5a | 104 ± 2.89b | 113 ± 0.00a,b |
Data are expressed as means ± SEM. Means with different letters differ, p < 0.05. Group 1, n = 5: focal injuries + apnea, hypoventilation; Group 2, n = 4: focal injuries + seizures; Group 3, n = 7: focal injuries + apnea, hypoventilation + seizures. *Treatment 1 tended to be different than treatment 3, p = 0.053.
BEEcf, Base excess in the extracellular fluid compartment; SEM, standard error of the mean.