Table 2.

Kaplan–Meier probability estimates with 95% CI

	Probability of first response over time
	3 months	6 months	9 months	12 months
TAU	0 (0, 0.03)	0.10 (0.07, 0.15)	0.19 (0.15, 0.24)	0.24 (0.19, 0.30)
VNS + TAU	0.01 (0, 0.03)	0.22 (0.17, 0.27)	0.33 (0.28, 0.38)	0.42 (0.36, 0.47)
	Probability of retaining the first response (response durability) over time
TAU	0.75 (0.63, 0.84)	0.58 (0.45, 0.69)	0.41 (0.29, 0.53)	0.39 (0.27, 0.51)
VNS + TAU	0.85 (0.78, 0.9)	0.65 (0.57, 0.73)	0.52 (0.43, 0.6)	0.47 (0.38, 0.56)
	Probability of second response over time following relapse from the first response
TAU	0	0.13 (0.06, 0.27)	0.27 (0.16, 0.43)	0.32 (0.20, 0.48)
VNS + TAU	0.07 (0.04, 0.15)	0.26 (0.18, 0.36)	0.44 (0.35, 0.55)	0.47 (0.37, 0.58)
	Probability of retaining second response (response durability) over time
TAU	0.97 (0.79, 1)	0.82 (0.63, 0.92)	0.63 (0.42, 0.78)	0.46 (0.27, 0.64)
VNS + TAU	0.98 (0.89, 1)	0.89 (0.78, 0.95)	0.73 (0.59, 0.82)	0.66 (0.52, 0.77)

Abbreviations: TAU, treatment as usual; VNS, vagus nerve stimulation.