Table 4.
Prognostic factors for overall survival after brain metastases in all patients
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| X2 | P-value | HR | 95% CI | P-value | ||
| Age (years) | ||||||
| <65 | 4.602 | 0.032 | ||||
| ≥65 | ||||||
| Sex | ||||||
| Male | 0.04 | 0.841 | ||||
| Female | ||||||
| ECOG | ||||||
| 0 | 12.347 | 0.002 | ||||
| 1 | ||||||
| ≥2 | ||||||
| RPA classification | ||||||
| 1 | 14.645 | 0.001 | 1 | 0.006 | ||
| 2 | 1.646 | 1.164–2.329 | 0.005 | |||
| 3 | 2.441 | 1.232–4.835 | 0.011 | |||
| Primary tumor | ||||||
| Lung | 28.581 | 0.000 | 1 | 0.001 | ||
| Breast | 1.133 | 0.771–1.665 | 0.526 | |||
| Gastrointestinal tract | 2.339 | 1.476–3.706 | 0.000 | |||
| Kidney | 1.476 | 0.894–2.437 | 0.128 | |||
| Other | 0.731 | 0.456–1.173 | 0.194 | |||
| Prior WBRT | ||||||
| Yes | 0.842 | 0.359 | ||||
| No | ||||||
| No. of brain metastases | ||||||
| 1 | 3.945 | 0.267 | ||||
| 2 | ||||||
| 3 | ||||||
| ≥4 lesions | ||||||
| Neurologic symptoms | ||||||
| Yes | 5.884 | 0.015 | ||||
| No | ||||||
| Cystic brain metastases | ||||||
| Yes | 2.091 | 0.148 | ||||
| No | ||||||
| Extracranial metastases | ||||||
| Yes | 7.669 | 0.006 | ||||
| No | ||||||
| The volume of total BM (cm3) | ||||||
| ≤8 | 9.001 | 0.011 | 1 | 0.006 | ||
| 8–27 | 1.243 | 0.958–1.613 | 0.102 | |||
| >27 | 2.146 | 1.314–3.505 | 0.002 | |||
| Primary tumor status | ||||||
| Control | 3.046 | 0.081 | ||||
| Uncontrol | ||||||
Abbreviations: BM, brain metastases; ECOG, Eastern Cooperative Oncology Group; RPA, recursive partitioning analysis; WBRT, whole brain radiotherapy.