Table 6.
Summary of studies of patients with brain metastases who underwent radiotherapy (stereotactic radiosurgery)
| Author and publication year | Primary tumor and characteristic of brain metastases | No. of patients | Treatment | Median survival time (months) | Local control |
|---|---|---|---|---|---|
|
| |||||
| Gerosa et al. (2002)21 | Multiple primary tumor | 804 | GK | 13.5 | 1 year: 94% |
| Pan et al. (2005)15 | Lung cancer | 191 | GK | GK alone: 15; WBRT + GK: 14 | 84.4% (<0.5 cm3); 94% (0.5–2 cm3); 89.1% (2–4 cm3); 93.4% (4–8 cm3); 85.7% (8–14 cm3; 87.5% (>14 cm3) |
|
| |||||
| Franzin et al. (2008)22 | Multiple primary tumor | 30 | GK | 15 | 91.3% |
|
| |||||
| Park et al. (2009)23 | Multiple primary tumor (cystic BM) | 24 | GK | 17.8 | 79.2% |
|
| |||||
| Fahed et al. (2014)24 | NSCLC | 89 | GK | 24 | 1 year: 91.5 2 years: 85.5% |
|
| |||||
| Keisuke et al. (2015)10 | NSCLC: 64 SCLC: 3 | 67 | CK | 13.1 | 1 year: 83.3% 2 years: 78.5% |
|
| |||||
| Sang et al. (2016)24 | Multiple primary tumor (cystic BM) | 28 | GK | 17.7 | 1 year: 82.3% |
|
| |||||
| Wang et al. (2016)26 | Multiple primary tumor (cystic BM) | 48 | GK | 19.5 | 91.7% |
|
| |||||
| Antonio et al. (2016)27 | Multiple primary tumor | 223 | CK | 11 | 1 year: 85% |
Abbreviations: BM, brain metastases; CK, CyberKnife; GK, Gamma Knife; NSCLC, non-small-cell lung cancer; SCLC, small cell lung cancer; WBRT, whole brain radiotherapy.