Table 1.
Resistance gene | Resistance gene function | Classification of resistance function | Estimated source organism | AMP |
---|---|---|---|---|
IpxFa | Lipid A 4'- phosphatase | Target alteration | Parabacteroides merdae | Polymyxin B, Pexiganan |
IpxFb | Lipid A 4'- phosphatase | Parabacteroides sp. | Polymyxin B, Pexiganan | |
IpxFc | Lipid A 4'- phosphatase | NA | Polymyxin B | |
arnTEF | 4-amino-4-deoxy-L-arabinose modification of Lipid-A | Escherichia coli MS 107-1 | Polymyxin B | |
pmrAB (qseBC) | Response regulator | Regulation | Sutterella wadsworthensis 2_1_59BFAA | Polymyxin B |
pmrD | Signal transduction protein | Escherichia coli MS 107-1 | Polymyxin B | |
ompT | Protease 7 precursor | Agent inactivation | Escherichia coli MS 196-1 | Bactenecin 5, LL37, Pexiganan |
characterized in this work (Fig. 4b, Fig. 4c and Fig.Supplementary Fig. 11); annotated as un-decaprenyl pyrophosphate phosphatase in Supplementary Table 6
annotated as bcrC in Supplementary Table 6
annotated as ybjG in Supplementary Table 10