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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: J Org Chem. 2019 Jan 25;84(4):2061–2071. doi: 10.1021/acs.joc.8b03072

Scheme 1:

Scheme 1:

Catalytic One-Step Deoxytrifluoromethylation Reaction: (a–b) Shortens the Synthesis of Known Intermediates to the Synthesis of COX-2 Inhibitor L-784,512 and a Fluorinated Analog of Tebufenpyrad; (c) Is Equally Efficient on Multi-Gram Scale.