Table 3:

Phenyl Bromodifluoroacetate Enables Cu-catalyzed One-pot Deoxytrifluoromethylation of Propargylic Alcohols^a

^aStandard reaction conditions: 5a–5f (0.50 mmol), 1d (1.0 mmol), CuI (0.050 mmol), 1,10-phenanthroline (0.055 mmol), HO₂CCF₂Br (0.25 mmol), KF (1.0 mmol), DMF (1.0 mL), 50 °C. Yield of material after chromatographic purification. For comparison, two-pot yields reported from reference 8c.