Table II.
Combined grade 2 and 3 toxicities of cycle 1 UCN-01 alone*.
| Toxicity type | Grade 2 or 3 | Toxicity type | Grade 2 or 3 |
|---|---|---|---|
| Amylase | 2(11%) | Hypoxia | 6(33%) |
| Anorexia | 3(l6%) | Inf w/o neut | 2(11%) |
| Chest pain | 3(l6%) | Leukopenia | 3(16%) |
| Creatinine | 4(22%) | Lymphopenia | 5(27%) |
| Dyspnea-SOB | 2(l1%) | Myalgia | 2(11%) |
| Fatigue | 3(l6%) | Nausea | 8(44%) |
| Headache | 8(44%) | Neutropenia | 4(22%) |
| Hemoglobin | 6(33%) | Rash/desquamation | 2(11%) |
| Hyperglycemia | 12(67%) | SGOT (AST) | 3(16%) |
| Hypermagnesemia | 3(16%) | Stomatitis | 3(16%) |
| Hypoalbuminemia | 2(11%) | Sup/vnt arrh | 2(11%) |
| Hypocalcemia | 6(33%) | Trans prbcs | 3(16%) |
| Hyponatremia | 2(11%) | Tumor lysis | 3(16%) |
| Hypotension | 4(2%) | Vomiting | 4(22%) |
SOB, shortness of breath; Inf w/o neut, infection without neutropenia; SGOT (AST), serum glutamic oxaloacetic transaminase (aspartate transaminase); Sup/vnt arrh, supraventricular arrhythmia; Trans prbcs, transfused packed red blood cells; SGPT, serum glutamic pyruvic transaminase; CPK, creatine phosphokinase.
*
Not included in the above table are the following grade 3 toxicities that occurred one time during cycle 1: isolated elevated SGPT and one episode of febrile neutropenia. Single episodes of grade 2 toxicities included an elevated bicarbonate level, circulation cardiac-other, constipation, an elevated CPK, depression, dyspepsia, pruritus, and taste disturbance.