Table III.

Summary of combined grade 2 and grade 3 toxicities for 32 cycles given at dose level 5^*.

Toxicity type	Grade 2 or 3	Toxicity type	Grade 2 or 3
Constipation	3	Hypokalemia	1
Dyspnea-SOB	4	Inf w/o neutropenia	1
Fatigue	2	Inf + 3/4 neutropenia	2
Febrile neutropenia	1	Leukopenia	13
Hem + 3/4 cyto	1	Lymphopenia	15
Hemoglobin	7	Nausea	3
Hyperglycemia	7	Neutropenia	8
Hypermagnesemia	5	Platelets	5
Hypoalbuminemia	2	Stomatitis	1
Hypocalcemia	5	Trans prbcs	7

SOB, shortness of breath; Hem, hemoglobin; cyto, cytopenia; Inf. w/o, infection without; Trans prbcs, transfused packed red blood cells.

^*Not included in the above table are the following grade 2 toxicities that occurred one time during dose level 5: anorexia, diarrhea, hyperkalemia, hypotension, photosensitivity, vomiting, and weight loss. One grade 3 rash/desquamation event was noted.