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UCN-01 pharmacokinetic parameter estimates (cycle 1) after 72 h IV infusion at 45 mg/m2/day*.
| Cmax (μg/mL) | AUC (0-∞) (μg.h/mL) | CLtot (mL/m2.h) | VλZ (L) | t1/2 (h) | |
|---|---|---|---|---|---|
| n | 15 | 15 | 15 | 15 | 15 |
| Median | 16.7 | 7258 | 23.7 | 7.4 | 360.6 |
| (Range) | (7.9–37.5) | (1089.8–14 348.9) | (4.8–89.0) | (3.2–17.5) | (32.7–856.2) |
Pharmacokinetic parameters were calculated using non-compartmental analysis. Abbreviations used in this table are defined in the text.
