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. 2019 Feb 24;2019(2):CD010406. doi: 10.1002/14651858.CD010406.pub3

Boudreault 2011.

Methods Single‐centre retrospective cohort
Participants Country: USA (Washington)
Setting: in‐hospital
Number of individuals: 143
Inclusion criteria: individuals undergoing haematopoietic stem cell transplantation presenting with respiratory tract infections
Definition of influenza: laboratory confirmed
Influenza type: seasonal
Median age (years): cohort 42.0 (IQR 31.0 to 53.0); no CS group 42.0 (IQR 32.0 to 51.0); low‐dose CS group 42.0 (IQR 28.0 to 53.0); high‐dose CS group 40.0 (IQR 32.0 to 54.0)
Male sex: cohort 83 (58.0); no CS group 36 (57.0); low‐dose CS group 29 (67.0); high‐dose CS group 18 (49.0)
Interventions Groups: No CS (n = 63); low‐dose CS (n = 43); high‐dose CS (n = 37)
Definitions for dose: low‐dose (prednisolone/methylprednisolone < 1 mg/kg/day); high‐dose (prednisolone/methylprednisolone >= 1 mg/kg/day) (dose considered was the highest dose taken during the 2 weeks preceding the influenza diagnosis)
Co‐interventions: antiviral therapy
Outcomes Time to death/time to influenza‐associated death: hazard ratios presented following multivariate analysis. Variables in the multivariate models included CS treatment, antiviral therapy, and lymphocyte count
Hypoxaemia
Lower respiratory tract disease
Mechanical ventilation
Adverse events: prolonged viral shedding
Risk of bias (Newcastle‐Ottawa Scale) Time to death
Selection domain score (max 4): 2
Comparability domain score (max 2): 1 (no adjustment for age/disease severity)
Outcome domain score (max 3): 2
Notes