Table 3.

Summary of the main gaps in pediatric status epilepticus literature and how pSERG is aiming to address them.

Areas	Main knowledge gaps in pediatric status epilepticus literature	pSERG strategies to address these gaps
Epidemiology	Clinical and genetic risk factors that contribute to refractoriness	Genetic analyses of patients with RCSE
	Correlation between etiology, response to different treatments and long-term outcome	Long-term outcome evaluation with a particular focus in function and neurocognitive function
	Data on receptor changes during status epilepticus in human brain	Collection of human brain samples from epilepsy surgery and autopsies
	Long-term clinical and developmental sequelae and mortality	Long-term follow-up with a focus on mortality and function
Diagnosis	Indications and yield of lumbar puncture, toxicologic studies	Collection of data on the yield of these tests when clinically used
Treatment	Optimal first-line therapy	Comparative effectiveness of first-line therapies
	Optimal second-line therapy	Comparative effectiveness of second-line therapies
	Optimal third-line therapy	Comparative effectiveness of third-line therapies
	Optimal continuous infusion	Comparative effectiveness of continuous infusions
	Role of emerging therapies	Descriptive analysis of the efficacy of emerging therapies in a large population
	Timing and escalation of treatments	Observational studies on the timing and escalation of drugs
	Potential role of polytherapy and combinations of different treatments	Descriptive analysis of the efficacy of polytherapy when clinically used
	Lack of comparative effectiveness studies	Performance of comparative effectiveness studies
	Lack of interventional treatment trials	Performance of interventional treatment trials