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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: Methods. 2018 Dec 6;155:49–57. doi: 10.1016/j.ymeth.2018.12.002

Figure 1.

Figure 1.

Epitope-tagging the endogenous RBP via genome editing. (A) Outline of the CRISPR/Cas9-based approach for epitope-tagging the endogenous RBP locus. (B) Outline of the procedures of using this approach to generate epitope-tag knock-in mouse. (C) Outline of the procedures of using this approach to generate bi-allelic knock-in cell lines.