Table 3.

Twenty VUS with susceptibility to be likely pathogenic.

ID	Gene	Mutation type	HGVS_P	CHR	POS	REF	ALT	intervar_evide	Pop_Freq	Degrees
E10335	TP53	Missense variant	p.Val197Glu	17	7578259	A	T	PM1;PM2;PP3	0	VUS
E09012	BRIP1	Missense variant	p.Gln102Arg	17	59934493	T	C	PM1;PM2;BP4	0	VUS
E09012	PDGFRA	Missense variant	p.Thr234Ile	4	55131158	C	T	PM1;PM2;PP3	0	VUS
E09012	APC	Missense variant	p.Leu662Ile	5	112173275	C	A	PM1;PM2;PP3	9.00E-04	VUS
E09117	POLE	Missense variant	p.Arg793His	12	133241978	C	T	PM1;PM2;PP3	1.22E-04	VUS
E09151	MSH2	Missense variant	p.Ile735Val	2	47703703	A	G	PM1;PM2;PP3	0.001	VUS
E09162	BRIP1	Missense variant	p.Leu340Phe	17	59878736	G	A	PM1;PM2;PP3	2.00E-04	VUS
E10164	PMS2	Missense variant	p.Pro771Gln	7	6017352	G	T	PM1;PM2;PP3	5.82E-05	VUS
E10168	NTHL1	Missense variant	p.Pro125Thr	16	2096134	G	T	PM1;PM2;PP3	5.80E-05	VUS
E10220	NF2	Missense variant	p.Ile487Leu	22	30074197	A	C	PM1;PM2;BP4	0	VUS
E10308	PMS2	Missense variant	p.Val302Phe	7	6031688	C	A	PM1;PM2;PP3	1.00E-04	VUS
E10315	CHEK2	Missense variant	p.Ser252Asn	22	29107934	C	T	PM1;PM2;PP3	0.001	VUS
E10354	NF2	Missense variant	p.Arg376Gln	22	30069262	G	A	PM1;PM2;PP3	1.14E-05	VUS
E11214	STK11	Missense variant	p.Arg42Leu	19	1207037	G	T	PM1;PM2;BP4	8.00E-04	VUS
E11235	BARD1	Missense variant	p.Arg99Lys	2	215657089	C	T	PM1;PM2;PP3	0	VUS
E11303	BRCA2	Missense variant	p.Ala2911Glu	13	32950906	C	A	PM2;PM3;PP5	0	VUS
E11348	TSC2	Missense variant	p.Val67Phe	16	2100461	G	T	PM1;PM2;PP3	0	VUS
E12047	MLH1	Missense variant	p.Ser368Leu	3	37067192	C	T	PM1;PM2;PP4	0.001	VUS
E12173	POLD1	Missense variant	p.Gly504Arg	19	50910363	G	C	PM1;PM2;PP5	0	VUS
E12269	MLH1	Missense variant	p.Val152Met	3	37050305	C	A	PM1;PM2;PP6	8.13E-06	VUS

VUS, variants of uncertain significance; PM, moderate pathogenicity; PP, supporting pathogenicity; BP, benign supporting pathogenicity. (The interpretation and grade of the sequence variants refer to PMID 25741868.)