Comparison 3. Misoprostol vs Placebo or no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death	4	3497	Risk Ratio (IV, Random, 95% CI)	1.00 [0.10, 9.59]
2 PPH >= 1000 mL	8	5467	Risk Ratio (IV, Random, 95% CI)	0.73 [0.56, 0.95]
3 Blood transfusion	6	3134	Risk Ratio (IV, Random, 95% CI)	0.46 [0.15, 1.47]
4 Severe maternal morbidity: intensive care admissions	1	1620	Risk Ratio (IV, Random, 95% CI)	1.00 [0.14, 7.05]
5 Severe maternal morbidity: shock	0	0	Risk Ratio (IV, Random, 95% CI)	0.0 [0.0, 0.0]
6 PPH >= 500 mL	7	4047	Risk Ratio (IV, Random, 95% CI)	0.75 [0.59, 0.94]
7 Additional uterotonics	8	3746	Risk Ratio (IV, Random, 95% CI)	0.67 [0.52, 0.87]
8 Blood loss	8	4146	Mean Difference (IV, Random, 95% CI)	‐42.07 [‐52.47, ‐31.68]
9 Change in haemoglobin	5	2334	Mean Difference (IV, Random, 95% CI)	‐2.53 [‐3.53, ‐1.52]
10 Breastfeeding	0	0	Risk Ratio (IV, Random, 95% CI)	0.0 [0.0, 0.0]
11 Nausea	4	3997	Risk Ratio (IV, Random, 95% CI)	1.18 [0.78, 1.78]
12 Vomiting	6	4949	Risk Ratio (IV, Random, 95% CI)	1.41 [0.92, 2.16]
13 Headache	1	1116	Risk Ratio (IV, Random, 95% CI)	0.94 [0.32, 2.77]
14 Abdominal pain	4	1894	Risk Ratio (IV, Random, 95% CI)	0.98 [0.29, 3.37]
15 Hypertension	0	0	Risk Ratio (IV, Random, 95% CI)	0.0 [0.0, 0.0]
16 Shivering	9	5286	Risk Ratio (IV, Random, 95% CI)	2.94 [2.38, 3.64]
17 Fever	5	4396	Risk Ratio (IV, Random, 95% CI)	4.09 [2.01, 8.32]
18 Diarrhoea	6	4791	Risk Ratio (IV, Random, 95% CI)	2.80 [1.21, 6.49]
19 Maternal well‐being	0		Risk Ratio (IV, Random, 95% CI)	Totals not selected
20 Maternal satisfaction	0		Risk Ratio (IV, Random, 95% CI)	Totals not selected