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. 2018 Dec 19;2018(12):CD011689. doi: 10.1002/14651858.CD011689.pub3

Comparison 42. Injectable prostaglandins vs Misoprostol (by mode of birth).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Death 1 100 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.1 Vaginal birth 1 100 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
1.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
2 PPH >= 1000 mL 2 170 Risk Ratio (IV, Random, 95% CI) 5.0 [0.25, 99.16]
2.1 Vaginal birth 2 170 Risk Ratio (IV, Random, 95% CI) 5.0 [0.25, 99.16]
2.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
3 Blood transfusion 4 403 Risk Ratio (IV, Random, 95% CI) 0.88 [0.14, 5.39]
3.1 Vaginal birth 4 403 Risk Ratio (IV, Random, 95% CI) 0.88 [0.14, 5.39]
3.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4 Severe maternal morbidity: intensive care admissions 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
4.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5 Severe maternal morbidity: shock 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
6 PPH >= 500 mL 3 303 Risk Ratio (IV, Random, 95% CI) 1.60 [0.57, 4.52]
6.1 Vaginal birth 3 303 Risk Ratio (IV, Random, 95% CI) 1.60 [0.57, 4.52]
6.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7 Additional uterotonics 4 403 Risk Ratio (IV, Random, 95% CI) 1.02 [0.28, 3.69]
7.1 Vaginal birth 4 403 Risk Ratio (IV, Random, 95% CI) 1.02 [0.28, 3.69]
7.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
8 Blood loss 3 270 Mean Difference (IV, Random, 95% CI) 52.99 [‐39.74, 145.71]
8.1 Vaginal birth 3 270 Mean Difference (IV, Random, 95% CI) 52.99 [‐39.74, 145.71]
8.2 Caesarean 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
9 Change in haemoglobin 2 220 Mean Difference (IV, Random, 95% CI) 2.28 [‐1.35, 5.90]
9.1 Vaginal birth 2 220 Mean Difference (IV, Random, 95% CI) 2.28 [‐1.35, 5.90]
9.2 Caesarean 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10 Breastfeeding 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
10.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
11 Nausea 2 233 Risk Ratio (IV, Random, 95% CI) 0.23 [0.06, 0.92]
11.1 Vaginal birth 2 233 Risk Ratio (IV, Random, 95% CI) 0.23 [0.06, 0.92]
11.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12 Vomiting 2 233 Risk Ratio (IV, Random, 95% CI) 1.31 [0.01, 163.15]
12.1 Vaginal birth 2 233 Risk Ratio (IV, Random, 95% CI) 1.31 [0.01, 163.15]
12.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13 Headache 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14 Abdominal pain 2 233 Risk Ratio (IV, Random, 95% CI) 0.99 [0.20, 4.80]
14.1 Vaginal birth 2 233 Risk Ratio (IV, Random, 95% CI) 0.99 [0.20, 4.80]
14.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15 Hypertension 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15.1 Vaginal birth 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
16 Shivering 3 353 Risk Ratio (IV, Random, 95% CI) 0.04 [0.01, 0.21]
16.1 Vaginal birth 3 353 Risk Ratio (IV, Random, 95% CI) 0.04 [0.01, 0.21]
16.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
17 Fever 2 233 Risk Ratio (IV, Random, 95% CI) 0.08 [0.01, 0.39]
17.1 Vaginal birth 2 233 Risk Ratio (IV, Random, 95% CI) 0.08 [0.01, 0.39]
17.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
18 Diarrhoea 2 233 Risk Ratio (IV, Random, 95% CI) 9.03 [1.70, 48.00]
18.1 Vaginal birth 2 233 Risk Ratio (IV, Random, 95% CI) 9.03 [1.70, 48.00]
18.2 Caesarean 0 0 Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19 Maternal well‐being 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
19.1 Vaginal birth 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
19.2 Caesarean 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20 Maternal satisfaction 0   Risk Ratio (IV, Random, 95% CI) Totals not selected
20.1 Vaginal birth 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20.2 Caesarean 0   Risk Ratio (IV, Random, 95% CI) 0.0 [0.0, 0.0]